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KMID : 1151820170110040177
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Journal of the Korean Society of Radiology
2017 Volume.11 No. 4 p.177 ~ p.181
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Comparison of Parameter Using the Repair Survival Model Irradiated High-LET
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Choi Eun-Ae
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Abstract
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Dose response curves using absorbed dose to the biological effect are usually available in case of conventional X beam. However, absorbed dose is not consider in treatment planning for carbon beam such as heavy ions. Because the biological effects also depend on other quantities such as the local variation, which is often characterized by the linear energy transfer (LET). So LQ model cannot explain the entire response of fractionated carbon beam irradiation. The variation in LET with penetration depth leads to substantial differences in biological effect of carbon beam. And it is therefore essential in treatment planning to calculate not only the absorbed dose but also the LET to estimate the biological outcome of the radiation of interest. LET variation plays an important role in the fractionated irradiations. It is suggested that consideration of LET is necessary in biophysical model.
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KEYWORD
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LET, Carbon beam, biophysical model, Marchese model, Repair survival model
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